Antidiabetic activity medicinal plant aegle marmelos. To evaluate hypoglycemic activity in alloxan induced diabetic rats similar doses once daily for 15 days. Molecular approach to identify antidiabetic potential of. The latinized name of neem azadirachta indica is derived from the persian.
Kumar2 1school of pharmaceutical sciences, siksha o anusandhan university, kalinga nagar, ghatikia, bhubaneswar751003, odisha, india. This chemicals are isolated and separate out from the. Melia azadirachta is well known in india and its neighbouring countries for more than 2000 years as one of the most versatile medicinal plants having a wide spectrum of biological activity. It has been reported to have antimutagenic 22, antidia. Leaves seeds flowers fruits bark roots some of the chemicals or the active constituents which can be separate out are as follows. Bhavani, 2014 antidiabetic activity of aegle marmelos international research journal of pharmaceutical and biosciences irjpbs 2014. Azadirachta indica neem is a higly regarded tree in india for its potent medicinal properties, neem got its distinction of sarva roga nivarini one that could cure all ailments and ills during ancient times. Reversal of diabetic retinopathy in streptozotocin induced diabetic rats using traditional indian antidiabetic plant, azadirachta indica. Antidiabetic effects of catharanthus roseus, azadirachta indica, allium sativum and glimepride in experimentally diabetic induced rat. Antioxidant activity, antitumor activity, azadirachta indica neem, folk. Neem azadirachta indica showed potent activity in no radical scavenging assay, reducing power assay when compared with that of the standard ascorbic acid may be due to the presence of flavonoids. Azadirachta indica, commonly known as neem, nimtree or indian lilac, is a tree in the mahogany family meliaceae. Antidiabetic effects of ethanolic flower extract of hibiscus rosa sinensis l on alloxan induced diabetes in hyperlipidaemic experimental wister rats wnin 1abhijeet ghosh, 2 dr. Evidencebased complementary and alternative medicine.
Treatment of diabetes is complicated due to multifactorial nature of the disease. Each part of the neem tree has some medicinal property. Journal of applied pharmaceutical science, 7, 100105. In vivo antidiabetic evaluation of neem leaf extract in alloxan induced rats. Possible mechanism of action of azadirachta indica is presented as follows. Its bioactive constituents include azadirachtin antimalarial, gedunin antimalarial, antifungal, nimbidin antiinflammatory, antipyretic, hypoglycemic, antiulcerant. Full length research article effect ofazadirachta indica leaf extract onserum lipid profile changes in normal and streptozotocin induced diabetic rats. During the last five decades, apart from the chemistry of the neem compounds, considerable progress has been achieved regarding the biological activity and medicinal applications of neem.
Analgesic and antiinflammatory activity of hydroalcoholic extract of azadirachta indica leaf a. The study was conducted on diabetic rats, either having impaired glucose tolerance or reduced number and activity of. It has been widely used in chinese, ayurvedic, and unani medicines worldwide especially in indian subcontinent in the treatment and prevention of various diseases. Some of the active constituents of neem azadirachta indica are as follows. Am eimahmood, ob ogbonna and m raji, the antibacterial activity of azadirachta indica neem associated with eye and ear infections, journal of medicinal. Antimicrobial activity, azadirachta indica, pathogenic bacteria, leaf and bark extract. An antidiabetic and hypolipidemic effects from azadirachta indica leaves find, read and cite all. Molecular approach to identify antidiabetic potential of azadirachta. About azadirachta indica active constituents of neem. Most of the parts of neem tree were studied in details by. This study was design for the insilico investigation of azadirachta indica neem leaves active chemicals against pepck protein. Juss, from the meliaceae mahogany family, known as margosa or indian lilac, has long been recognized for its properties both against insects and in improving human health. Juss meliaceae have been used by folklore for a number of ailments.
The plant is native to asia, but has now naturalized in west africa. They are also used to treat small pox, chronic ulcers, swelling and wounds. A rewiew on antidiabetic angiospermic plants from the regions of uttarakhand, india 16 s r. Antidiabetic effects of ethanolic flower extract of. Azadirachtin from the neem tree azadirachta indica. Juss is the most useful traditional medicinal plant in india. Therapeutics role of azadirachta indica neem and their. The leaves when applied to the skin gives cooling effect on the skin. Neem azadirachta indica introduction neem or margosa is a botanical cousin of mahogany. Neem, guava, dpph, nitric oxide, reducing power, antidiabetic activity. Effect of aqueous extract of azadirachta indica leaves on. Earlier finding confirmed that neem and its constituents play. It is typically grown in tropical and semitropical regions. Cronicon open access ec pharmacology and toxicology.
Reversal of diabetic retinopathy in streptozotocin induced. About azadirachta indica in acne, pimples and skin. Furthermore, the study investigated effect of simultaneous administration of oj and metformin in diabetic rats. An antidiabetic and hypolipidemic effects from azadirachta indica leaves find, read and cite all the research you need. Juss family meliaceae is well known in india and its neighboring countries as one of the most versatile medicinal plants having wide spectrum of biological activity.
The pharmacokinetics and pharmacodynamics of glipizide was evaluated in high fat diet hfd and streptozotocin induced diabetic spraguedawley rats. Synergistic antidiabetic activity of vernonia amygdalina. The full text of this article is available as a pdf 1. Azad free, dirakht tree, i hind of indian origin which literally means. Juss, commiphora mukul, curcuma longa l, emblica officinalis gaertn, garcinia cambogia gaertn, gymnema sylvestre retz, momordica charantia l, ocimum sanctum l and trigonella foenumgraecum l. It is one of two species in the genus azadirachta, and is native to the indian subcontinent. Neem azadirachta indica is a member of the meliaceae family and its role as healthpromoting effect is attributed because it is rich source of antioxidant. Investigations in to the antidiabetic activity ofazadirachta indica. Review article biological activities and medicinal. Pdf diabetes mellitus dm is a metabolic syndrome, in which there is chronic.
They are very effective in the treatment in various skin diseases such as acne and pimples. Antidiabetic, antihyperlipidemic activities and herbdrug. Various religious documents such as bible and quran also supported the herbs. The present study deals with biochemical effects of the neem leaf water extract given orally. Blood sugar levels were estimated by using glucometer. Diabetes mellitus is a metabolic syndrome characterized by an increase in the blood glucose level. Medicinal plants have been reported to have antioxidant activity 22. Antidiabetic activity of vinca rosea extracts in alloxan. Request pdf antidiabetic activity of alcoholic extract of neem azadirachta indica root bark background. Previous studies show that azadirachta indica neem and its chief constituents play essential role in anticancer. In this study, total phenolics, flavonoids and vitamin c content visavis antioxidant activities were assayed in leaves and stem bark of azadirachta indica, butea monosperma, cassia fistula. Antidiabetic activity of alcoholic extract of neem. For the current study chemical structures of neem compounds were. A rewiew on antidiabetic angiospermic plants from the.
Antidiabetic property of azadirachta indica pak armed forces med j. Neem trees also grow in islands located in the southern part of iran. Neam leef, neem oil or other products of neem lowers the blood sugar level and hence useful for preventing diabetes. Introduction neem is used in traditional medicine as a source of many. Pdf azadirachta indica has been used medicinally throughout history by many different cultures. Most of the parts of neem tree were studied in details. The leaves of the neem tree azadirachta indica are very useful in skin diseases.
Invivo antidiabetic evaluation of neem leaf extract in alloxan. Full length research article effect ofazadirachta indica. Screening and design of antidiabetic compounds sourced from the leaves of neem azadirachta indica. Neem is one of the traditional herb or plant which is used to treat diabetes. In the present study using in vivo diabetic murine model, a. Azadirachta indica is one of the effective plant for the treatment and prevention of the diabetes. Therapeutics role of azadirachta indica neem and their active. Hypoglycemic activity of the concentrated ethanolic 90% extract of azadirachta indica and andrographis peniculata were studied compared with that of a reference antidiabetic drug glimeperide in both glucose loaded and alloxan induced diabetic rats. We have examined the pharmacological hypoglycemic action of azadirachta indica in diabetic rats.
The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. In the present study using invivo diabetic murine model, a. Pdf study of antidiabetic activities of endophytic fungi. Biochemical studies on hypoglycemic agents i effect ofazadirachta. Most of the parts of neem tree were studied in details by many researchers but neem root. The formulation was prepared using ingredients of azadirachta indica a. Antidiabetic activity of alcoholic extract of neem azadirachta indica. As part of an investigation into the antidiabetic mechanism of some indigenous medicinal plants, the proximate, vitamins and mineral elements and phytochemical compositions of azadirachta indica, vernonia amygdalina and gongronema latifolium were quantitatively determined using standard methods and compared. Preliminary phytochemical screening and in vitro anti. Juss and bougainvillea spectabilis are reported to have medicinal values including antidiabetic properties. Pdf on jul 1, 2011, dinesh kumar and others published azadirachtolide. The present study was a 28day investigation into the reported synergistic antidiabetic action of vernonia amygdalina del. Abhijit dutta 1research scholar, 2associate professor zoology 1university department of zoology, 1ranchi university, morhabadi, ranchi.
About azadirachta indica antidiabetic activity using neem. With this background, the present research work was undertaken to standardize and evaluate antidiabetic and antihyperlipidemic activities of a polyherbal formulation, ojamin, using streptozotocin stzinduced diabetic model in rats. This study was conducted to determine the interaction of glipizide gz with an aqueous extract of azadirachta indica azi leaves. Juss in streptozotocin diabetic rat models with the aim of elucidating the biochemical effects and possible mechanism by which the synergy is. Antidiabetic definition of antidiabetic by the free. Pdf in vivo antidiabetic evaluation of neem leaf extract. Background azadirachta indica neem is a communal plant of meliaceae family called neem or kadunimb in maharashtra, india neem stated antiinflammatory through regulation of proinflammatory enzyme activities with cox and lox enzyme. Many indian medicinal plants have been scientifically explored for their antidiabetic and antioxidant activities. A comparative study on antidiabetic and antioxidantic.
The leaf extract lowers the insulin requiremnt without affecting the other parts of. The neem tree is an attractive broad leaved evergreen which can grow up to 30m tall with spreading branches covering some 10 m across. Antinociceptive and antioxidant activities of methanolic. Screening and design of antidiabetic compounds sourced. The methanolic whole plant extract at high dose 500 mgkg exhibited significant antihyperglycemic activity than whole plant extract at low dose 300 mgkg in diabetic rats. Comparative chemical composition of leaves of some.
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